CCL18 from Tumor-Associated Macrophages Promotes Breast Cancer Metastasis via PITPNM3
نویسندگان
چکیده
منابع مشابه
CCL18 from tumor-associated macrophages promotes breast cancer metastasis via PITPNM3.
Tumor-associated macrophages (TAMs) can influence cancer progression and metastasis, but the mechanism remains unclear. Here, we show that breast TAMs abundantly produce CCL18, and its expression in blood or cancer stroma is associated with metastasis and reduced patient survival. CCL18 released by breast TAMs promotes the invasiveness of cancer cells by triggering integrin clustering and enhan...
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Breast cancer metastasis is the most common cause of cancer-related death in women. Thus, seeking targets of breast tumor cells is an attractive goal towards improving clinical treatment. The present study showed that CCL18 from tumor-associated macrophages could promote breast cancer metastasis via PITPNM3. In addition, we found that pachymic acid (PA) could dose-dependently inhibit migration ...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2011
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2011.02.006